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  • MOTS-c (Exercise Mimetic & AMPK Activator) | 5mg – 40mg Vials | >99% Purity

MOTS-c (Exercise Mimetic & AMPK Activator) | 5mg – 40mg Vials | >99% Purity

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49.99
99.99
Chemical Specifications
Product Name MOTS-c (Mitochondrial-Derived Peptide)
CAS Number 1627580-64-6
Molecular Formula C101H152N28O22S2
Protein Structure 16-Amino-Acid MDP encoded by mitochondrial 12S rRNA (H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH)
Molecular Weight ~2174.6 g/mol
Purity (HPLC) ≥ 99.0%
Appearance White Lyophilized Powder
Storage Store at -20°C (Protect from light and moisture)
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          Description
          🏃‍♂️

          What is MOTS-c?

          MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is not a conventional, nuclear-encoded peptide. Available in precise 5mg to 40mg lyophilized vials, MOTS-c is a master metabolic regulator universally known in advanced anti-aging research as “The Ultimate Exercise Mimetic.” It is a 16-amino-acid Mitochondrial-Derived Peptide (MDP) encoded directly by the mitochondrial genome itself. This unique origin grants it nuclear-level control over systemic metabolism. MOTS-c functions by potent, direct activation of the AMPK pathway in skeletal muscle, effectively “tricking” the body into a state of high-intensity aerobic exercise at the cellular level. This unlocks profound improvements in systemic fatty acid oxidation, insulin sensitivity, mitochondrial rejuvenation, and whole-body vitality, independent of actual physical activity.

          Key Features & Metabolic Protocols

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          The Ultimate Exercise Mimetic

          Functions by mimicking the systemic metabolic benefits of acute physical exercise. Triggers high-intensity fat oxidation and glucose uptake pathways, effectively simulating a workout’s energy demands.

          ⚡

          Metabolic Master Switch (AMPK)

          Upregulates the body’s primary energy sensor. Potently activates the AMP-activated protein kinase (AMPK) pathway, the defining regulator of muscle energy homeostasis and lipid metabolism.

          🛡️

          Reverse Mitochondrial Aging

          Targets the source of decay. Rejuvenates aged or dysfunctional mitochondria, increasing their number, size, and efficiency (mitochondrial biogenesis) for restored cellular energy production.

          🔥

          Systemic Fat Loss Engine

          Turns fat into fuel. Forces skeletal muscle cells to dramatically increase the consumption of stored fatty acids for energy, accelerating metabolic rate and improving body composition.

          🧬

          Retrograde Messaging (Mito-to-Nucleus)

          Operates outside traditional dogma. Translocates systemically from the mitochondria to the cell nucleus under stress to directly regulate nuclear gene expression related to longevity and metabolism.

          💎

          Verified High Purity (>99%)

          synthesized via advanced SPPS technology, ensuring a ≥99.0% purity level. Highly stable in sterile lyophilized powder form, ideal for reproducible in-vitro and systemic metabolic studies.

          How It Works: The Mitochondrial-Encoded Workout

          To understand the nuclear potency of MOTS-c, you must understand the body’s primary energy paradox. When you exercise, your cell nucleus sends a signal to your mitochondria (“the energy factories”) to work harder. MOTS-c is the exact opposite. While almost all other peptides originate from the cellular nucleus, MOTS-c is an exceptionally rare Mitochondrial-Derived Peptide (MDP) encoded entirely within the mitochondrial 12S rRNA region. It is the mitochondria’s own source code.

          MOTS-c is the definitive metabolic hack. Researchers took the natural MOTS-c sequence (a concise, powerful 16-amino-acid chain) and realized its true nuclear power. When introduced systemically, MOTS-c has a feroious affinity for skeletal muscle tissue. It travels systemically and potently, forcefully activating the AMPK pathway (AMP-activated protein kinase), often called the “Metabolic Master Switch.” This activation creates a recursive loop: AMPK activation tells the cell it is dangerously low on energy (ATP), thus “tricking” the skeletal muscle at the cellular level into believing it is undergoing high-intensity aerobic exercise. The cellular machinery is forced to upregulate **glucose uptake (specifically via GLUT4 translocation)** and, even more critically, violently accelerate Systemic Fatty Acid Oxidation (Beta-oxidation) for fuel. The result is a highly potent workout effect on entire tissue systems—dramatically enhancing mitochondrial biogenesis (the creation of new, youthful mitochondria) and systemically reversing the linear decline of mitochondrial function, all without systemic caloric expenditure.

          🧪 What’s In The Vial

          • Active Compound: MOTS-c (MDP)
          • Structure: 16-Amino-Acid Polypeptide
          • State: Sterile, Lyophilized Powder
          • Format: As selected (5mg – 40mg Vials)
          • Purity: ≥99.0% (HPLC Verified)

          👩‍🔬 Who Uses It

          • Metabolic Syndrome Researchers
          • Anti-Aging & Cellular Longevity Scientists
          • GHRH & GHS Interaction Studies (ss-31/nad+ synergy)
          • Exercise Physiology Labs (exercise mimetics)
          • Obesity & Glucose Homeostasis Investigators

          🔗 Best Paired With

          • Sterile Bacteriostatic Water (BAC)
          • SS-31 Peptide (For total mitochondrial support assay)
          • NAD+ / Mitochondrial Co-factors (to maximize synergy)
          • Targeted Metabolic Research Protocols